Bottle septa provide an airtight seal for bottles, to protect bottle contents from environmental contaminants while allowing content removal or addition via piercing with sharp needles. Generally available for open-top and screw caps, bottle septa allow for aseptic syringe dispensing, as well as the addition of materials. Replacement septa, available in multi-unit packaging, can be used as for bottles with unbonded septa; caps are available separately. Septa can generally be autoclaved or dry heat sterilized, and are available in a variety of materials, including PTFE, silicone, and red