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Novobiocin Sodium Salt, MP Biomedicals™
Inhibits DNA synthesis by inhibiting the enzyme Topoisomerase II. Novobiocin Sodium Salt, MP Biomedicals is an antibiotic produced by Streptomyces nieveus. It is active against gram-positive bacteria. It is also a Hsp90 inhibitor 3.
| Catalog Number | Quantity |
|---|---|
| MPB0215595725 | 25 g |
Catalog number MPB0215595725
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Quantity:
25 g
Specifications
Physical FormPowder
Absorbanceλ max: 307nm
CAS1476-53-5
Melting Point220°C
Extinction CoefficientE1%= 600 (0.1M NAOH)
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Inhibits DNA synthesis by inhibiting the enzyme Topoisomerase II. Novobiocin Sodium Salt, MP Biomedicals is an antibiotic produced by Streptomyces nieveus. It is active against gram-positive bacteria. It is also a Hsp90 inhibitor 3.
Novobiocin inhibits DNA synthesis by inhibiting bacterial DNA gyrase targeting the GyrB subunit of the enzyme involved in energy transduction. It acts as a competitive inhibitor of the ATPase reaction catalysed by GyrB 2. Uses include:
- For the production of positively supercoiled plasmid DNA
- Inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase
- Inhibitor of retrovirus RNA-dependent DNA-polymerase
- To study heat shock protein inhibition