Bosutinib, Tocris Bioscience™
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Bosutinib, Tocris Bioscience™
Bosutinib, Tocris Bioscience™
Bosutinib, Tocris Bioscience™

Bosutinib, Tocris Bioscience™

Dual Src-Abl inhibitor; antiproliferative
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Catalog NumberQuantity
436110
also known as 436110/SAMPLE
10 mg
Catalog number 436110
also known as 436110/SAMPLE
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Quantity:
10 mg
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Specifications
Chemical Name or MaterialBosutinib
CAS380843-75-4
Recommended StorageStore at +4°C
Molecular FormulaC26H29Cl2N5O3
MDL NumberMFCD07367846
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Dual inhibitor of Abl and Src kinases (IC50 = 1.2 nM for Src in an enzymatic assay). Displays antiproliferative activity against chronic myelogenous leukemia (CML) cells and decreases the motility and invasion of breast cancer cell lines. Also exhibits potent antiproliferative activity in anchorage-independent, Src-transformed rat fibroblasts (IC50 = 100 nM). Displays selectivity for Src over non-Src family kinases such as growth factor receptor tyrosine kinases.